RNAi Experiment: Cenix:201-f1 |
Ace View of Cenix:201-f1
|
Genes Inhibited |
 |
Gene Inhibited |
C14A4.4 (crn-3) |
Description of "C14A4.4" |
crn-3 encodes a cell death-related nuclease, homologous to the 100 kDa polymyositis/scleroderma autoantigen (PM/Scl-100), that is required for normal levels of DNA degradation during apoptosis; PM/Scl-100 is a ribonuclease component of the multiexonuclease exosome complex, which processes or degrades several types of RNAs in yeast; crn-3(RNAi) animals show retarded growth and a low penetrance of embryonic lethality; CRN-3 promotes both DNA degradation and cell corpse engulfment, in a partially redundant pathway that includes CRN-2 but is parallel to CPS-6; CRN-3 is predicted to be mitochondrial. |
Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (II:10588860..10590276)
Transcript overlap: 1390 nt |
|
Sliding Window |
Raw score: 1369
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
|
External "C14A4.4" Links |
1 2 |
Cenix:201-f1 Phenotypes |
|
 |
Phenotype |
WT
|
Cenix:201-f1 Experiment Details |
Ace View |
Laboratory |
TH |
RNAi Reagent & Type |
Cenix:201-f1 (PCR_reagent) |
Remark |
3/3 tests are wildtype. |
Reference |
Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
Delivery Method |
Injection |
Date |
2005-3-24 |
Gene Plot of C14A4.4 |
Browse using GBrowse
|
 |