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RNAi Experiment: Cenix:201-f1 Ace View of Cenix:201-f1
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C14A4.4 (crn-3)
Description of "C14A4.4"  crn-3 encodes a cell death-related nuclease, homologous to the 100 kDa polymyositis/scleroderma autoantigen (PM/Scl-100), that is required for normal levels of DNA degradation during apoptosis; PM/Scl-100 is a ribonuclease component of the multiexonuclease exosome complex, which processes or degrades several types of RNAs in yeast; crn-3(RNAi) animals show retarded growth and a low penetrance of embryonic lethality; CRN-3 promotes both DNA degradation and cell corpse engulfment, in a partially redundant pathway that includes CRN-2 but is parallel to CPS-6; CRN-3 is predicted to be mitochondrial.
Evidence for Inhibition 
ePCR Status: Unique_ePCR (II:10588860..10590276)
Transcript overlap: 1390 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 1369
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C14A4.4" Links  Wormbase NCBI Phenobank 1 2
Cenix:201-f1 Phenotypes Help with Phenotypes
Phenotype  WT
Cenix:201-f1 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:201-f1 (PCR_reagent)
Remark  3/3 tests are wildtype.
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of C14A4.4 Browse using GBrowse
Gene Graph