Ace View of Cenix:202-d2 | |||
Gene Inhibited | F52H3.1 (let-268) | ||
Description of "F52H3.1" | let-268 encodes a procollagen lysyl hydroxylase that processes type IV collagen, a collagen secreted and incorporated into the basement membrane during embryogenesis (and encoded partly by emb-9); LET-268 activity is essential for type IV collagen processing and secretion and for the stability, but not the formation of, the basement membrane that provides mechanical support to body wall muscle once contraction begins; LET-268 also appears to be required for pharyngeal muscle contraction. | ||
KOG Annotation  | Lysyl hydroxylase |
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Evidence for Inhibition | |||
External "F52H3.1" Links | 1 | ||
Embryonic | Emb Penetrance None reported | ||
Phenotype | WT_postembryonic_morphology |
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External Movies (Please note that RNAiDB is not hosting these data.) |
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Laboratory | TH | ||
RNAi Reagent & Type | Cenix:202-d2 (PCR_reagent) | ||
Remark | early embryonic: No significant defects. | ||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||
Delivery Method | Injection | ||
Date | 2005-3-24 | ||
Gene Plot of F52H3.1 | |||