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RNAi Experiment: Cenix:204-f5 Ace View of Cenix:204-f5
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F18A1.5
Description of "F18A1.5"  F18A1.5 encodes the C. elegans ortholog of the replication protein A (RPA) large subunit; by homology, the F18A1.5 gene product is predicted to function as a DNA binding and oligonucleotide oligosaccharide binding (OB) protein that is required for DNA replication, repair, and recombination; large-scale RNAi screens indicate that the product of F18A1.5 is essential for embryonic development, and that in yeast two-hybrid assays interacts with the product of M04F3.1, the RPA medium subunit; in situ hybridization studies indicate that F18A1.5 transcripts are expressed in germ cells.
KOG Annotation  Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (II:7665865..7666679)
Transcript overlap: 815 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 794
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F18A1.5" Links  Wormbase NCBI Phenobank 1
Cenix:204-f5 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Phenotype  Sister Chromatid Separation abnormal (Cross-eyed)
External Movies 
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Cenix:204-f5 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:204-f5 (PCR_reagent)
Remark  early embryonic: Sister Chromatid Separation (Cross-eyed)
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of F18A1.5 Browse using GBrowse
Gene Graph