| RNAi Experiment: Cenix:205-b10 |
Ace View of Cenix:205-b10
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| Genes Inhibited |
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| Gene Inhibited |
K10B2.1 (lin-23) |
| Description of "K10B2.1" |
lin-23 encodes an F-box- and WD-repeat-containing protein that is orthologous to Saccharomyces cerevisiae MET30 and human beta TRCP (OMIM:603482), both components of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; LIN-23 negatively regulates postembryonic cell divsions in all tissue types, and specifically, has been shown to function cell autonomously in the vulva to negatively regulate cell cycle progression and allow for cell cycle exit; LIN-23 is most highly expressed in the early embryo and adult germline. |
| KOG Annotation |
Beta-TrCP (transducin repeats containing)/Slimb proteins
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| Evidence for Inhibition |
| ePCR |
Status: Unique_ePCR (II:6371945..6373071)
Transcript overlap: 945 nt |
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| Sliding Window |
Raw score: 882
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
| Wormbase (BLAST) |
RNAi primary |
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| External "K10B2.1" Links |
   1 |
| Cenix:205-b10 Phenotypes |
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| Embryonic |
Emb Penetrance None reported |
| Phenotype |
WT_postembryonic_morphology
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External Movies
(Please note that RNAiDB is not
hosting these data.) |
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| Cenix:205-b10 Experiment Details |
Ace View |
| Laboratory |
TH |
| RNAi Reagent & Type |
Cenix:205-b10 (PCR_reagent) |
| Remark |
early embryonic: No significant defects. |
| Reference |
Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
| Delivery Method |
Injection |
| Date |
2005-3-24 |
| Gene Plot of K10B2.1 |
Browse using GBrowse
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