Link to T05A8.3Link to T05A8.4RNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentgeneMap
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RNAi Experiment: Cenix:207-g5 Ace View of Cenix:207-g5
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  T05A8.4
Description of "T05A8.4"  T05A8.4 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; while T05A8.4 is an ortholog of mammalian neutral endopeptidase (NEP), expressed on the brush-border membranes of kidney; more generally, T05A8.4 falls into a group of proteins that includes the classical neprilysins found in mammals (e.g., PEX [OMIM:307800] and the enkephalin cleaving enzymes).
KOG Annotation  M13 family peptidase
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (II:2721912..2723562)
Transcript overlap: 554 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 449
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "T05A8.4" Links  Wormbase NCBI Phenobank 1
Cenix:207-g5 Phenotypes Help with Phenotypes
Phenotype  WT
Cenix:207-g5 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:207-g5 (PCR_reagent)
Remark  3/3 tests are wildtype
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of T05A8.4 Browse using GBrowse
Gene Graph