Ace View of Cenix:208-a6 | |||
Gene Inhibited | F10B5.6 (emb-27) | ||
Description of "F10B5.6" | emb-27 encodes a tetratricopeptide repeat (TPR)-containing protein that is the C. elegans ortholog of the anaphase-promoting complex (APC) subunit APC-6 (CDC16); required maternally and paternally, EMB-27 activity is essential for proper execution of the metaphase-to-anaphase transition during meiosis (both oogenesis and spermatogenesis) and mitosis (during germline proliferation); EMB-27 activity is also critical for embryonic anterior-posterior (A-P) axis formation, production of the secreted eggshell, and normal vulval development; in establishing the embryonic A-P axis, EMB-27 likely acts upstream of the separin protease to ensure proper localization of PAR-3 and PAR-2 to the anterior and posterior cortices, respectively. | ||
KOG Annotation  | Anaphase-promoting complex (APC), Cdc16 subunit |
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Evidence for Inhibition | |||
External "F10B5.6" Links | 1 | ||
Embryonic | Emb Penetrance None reported | ||
Phenotype | Passage Through Meiosis defective |
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External Movies (Please note that RNAiDB is not hosting these data.) |
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Laboratory | TH | ||
RNAi Reagent & Type | Cenix:208-a6 (PCR_reagent) | ||
Remark | early embryonic: Passage Through Meiosis | ||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||
Delivery Method | Injection | ||
Date | 2005-3-24 | ||
Gene Plot of F10B5.6 | |||