Link to F10B5.5Link to F10B5.6.1Link to F10B5.6.2Link to F10B5.7RNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentgeneMap
Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
RNAi Experiment: Cenix:208-a6 Ace View of Cenix:208-a6
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F10B5.6 (emb-27)
Description of "F10B5.6"  emb-27 encodes a tetratricopeptide repeat (TPR)-containing protein that is the C. elegans ortholog of the anaphase-promoting complex (APC) subunit APC-6 (CDC16); required maternally and paternally, EMB-27 activity is essential for proper execution of the metaphase-to-anaphase transition during meiosis (both oogenesis and spermatogenesis) and mitosis (during germline proliferation); EMB-27 activity is also critical for embryonic anterior-posterior (A-P) axis formation, production of the secreted eggshell, and normal vulval development; in establishing the embryonic A-P axis, EMB-27 likely acts upstream of the separin protease to ensure proper localization of PAR-3 and PAR-2 to the anterior and posterior cortices, respectively.
KOG Annotation  Anaphase-promoting complex (APC), Cdc16 subunit
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (II:8160348..8162027)
Transcript overlap: 1451 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 1325
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F10B5.6" Links  Wormbase NCBI Phenobank 1
Cenix:208-a6 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Phenotype  Passage Through Meiosis defective
External Movies 
(Please note that RNAiDB is not
hosting these data.)
/static/images/movie.gif /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif
Cenix:208-a6 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:208-a6 (PCR_reagent)
Remark  early embryonic: Passage Through Meiosis
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of F10B5.6 Browse using GBrowse
Gene Graph