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RNAi Experiment: Cenix:21-b12 Ace View of Cenix:21-b12
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  B0261.2 (let-363)
Description of "B0261.2"  let-363 encodes, by alternative splicing, two large (>2600-residue) proteins with C-terminal similarity to phosphatidylinositol kinase (PIK); LET-363 proteins are orthologous to S. cerevisiae Tor1p and Tor2p and human FRAP1 (OMIM:601231, mammalian target of FKBP12-rapamycin); LET-363 proteins are required for progression through the L3 stage of larval development and are thought to generally stimulate translation of most or all mRNAs ('global translation'); LET-363 activity is also necessary for normal development and physiology of the intestine; LET-363 proteins are expressed ubiquitously, including a maternal contribution to the early embryo.
KOG Annotation  DNA-dependent protein kinase
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:5261120..5261631)
Transcript overlap: 501 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 480
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "B0261.2" Links  Wormbase NCBI Phenobank 1 2
Cenix:21-b12 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Phenotype  WT_postembryonic_morphology
External Movies 
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Cenix:21-b12 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:21-b12 (PCR_reagent)
Remark  early embryonic: No significant defects
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of B0261.2 Browse using GBrowse
Gene Graph