RNAi Experiment: Cenix:223-g3 |
Ace View of Cenix:223-g3
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Genes Inhibited |
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Gene Inhibited |
T27E4.2 (hsp-16.11) |
Description of "T27E4.2" |
hsp-16.11 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.1; hsp-16.11 expression is induced in response to heat shock or other environmental stresses; HSP-16.11 is likely to function as passive ligand temporarily preventing unfolded proteins from aggregating; HSP-16.11 has been shown to interact with intracellular human beta amyloid peptide, a primary component of the extracellular plaques found in Alzheimer's disease. |
Evidence for Inhibition |
ePCR |
Status: Best_ePCR (V:9092713..9092809)
Transcript overlap: 97 nt |
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Sliding Window |
Raw score: 76
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 0.5 |
Wormbase (BLAST) |
RNAi primary |
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External "T27E4.2" Links |
1 2 |
Gene Inhibited |
T27E4.8 (hsp-16.1) |
Description of "T27E4.8" |
hsp-16.1 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.11; an hsp-16.1 reporter fusion, expressed broadly but most strongly in muscle and hypodermis, is induced solely in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.1 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. |
KOG Annotation  |
Alpha crystallins
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Evidence for Inhibition |
ePCR |
Status: Best_ePCR (V:9090262..9090358)
Transcript overlap: 97 nt |
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Sliding Window |
Raw score: 76
Specificity index: 0.5 |
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External "T27E4.8" Links |
1 2 |
Cenix:223-g3 Phenotypes |
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Phenotype |
WT
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Cenix:223-g3 Experiment Details |
Ace View |
Laboratory |
TH |
RNAi Reagent & Type |
Cenix:223-g3 (PCR_reagent) |
Remark |
Wildtype results in all three tests. |
Reference |
Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
Delivery Method |
Injection |
Date |
2005-3-24 |
Gene Plot of T27E4.8 |
Browse using GBrowse
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Gene Plot of T27E4.2 |
Browse using GBrowse
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