RNAi Experiment: Cenix:235-a4 |
Ace View of Cenix:235-a4
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Genes Inhibited |
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Gene Inhibited |
R05F9.3 (msp-32) |
Description of "R05F9.3" |
msp-32 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-32 has a C. briggsae homolog as predicted by the Wobble Aware Bulk Aligner (WABA); the msp family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. |
Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (II:4898622..4898726)
Transcript overlap: 105 nt |
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Sliding Window |
Raw score: 63
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "R05F9.3" Links |
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Cenix:235-a4 Phenotypes |
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Phenotype |
WT
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Cenix:235-a4 Experiment Details |
Ace View |
Laboratory |
TH |
RNAi Reagent & Type |
Cenix:235-a4 (PCR_reagent) |
Remark |
Wildtype results in all three tests. |
Reference |
Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
Delivery Method |
Injection |
Date |
2005-3-24 |
Gene Plot of R05F9.3 |
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