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RNAi Experiment: Cenix:30-h5 Ace View of Cenix:30-h5
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C09G4.5 (mes-6)
Description of "C09G4.5"  mes-6 encodes a WD repeat-containing protein that is orthologous to Drosophila Extra sex combs (Esc); as a member of a Polycomb-like chromatin repressive complex with MES-2 and MES-3, MES-6 is required maternally for normal germline development and during larval development, for anteroposterior patterning; during germline development, the MES-2/MES-3/MES-6 complex is believed to be essential for maintaining repression of the X chromosome, and in transgenic animals, the complex is necessary for germline repression of repetitive transgenes; in axial patterning, the MES-2/MES-3/MES-6 complex is required in somatic tissues for maintaining homeotic gene repression, acting upstream of the Hox genes lin-39, mab-5, and egl-5, as well as the egl-5 target gene lin-32; MES-6 expression is detected in the nuclei of all cells during early embryogenesis, in the germline precursors Z2 and Z3 and faintly in some somatic cells during late embryogenesis and the L1 larval stage, widely in later larvae, and in germline and oocyte nuclei in adults; normal MES-6 distribution is dependent upon wild-type activity of MES-2 and MES-3, and likewise, distribution of MES-3 is dependent upon wild-type activity of MES-2 and MES-6
KOG Annotation  Transcriptional repressor EED/ESC/FIE, required for transcriptional silencing, WD repeat superfamily
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (IV:8511543..8513203)
Transcript overlap: 1151 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 1004
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C09G4.5" Links  Wormbase NCBI Phenobank 1 2
Cenix:30-h5 Phenotypes Help with Phenotypes
Phenotype  WT
External Movies 
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hosting these data.)
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Cenix:30-h5 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:30-h5 (PCR_reagent)
Remark  early embryonic: Overall wildtype.
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of C09G4.5 Browse using GBrowse
Gene Graph