Ace View of Cenix:300-a9 | |||
Gene Inhibited | T04A8.14 (emb-5) | ||
Description of "T04A8.14" | emb-5 encodes the C. elegans ortholog of the Spt6 family of RNA polymerase II transcription elongation factors; first identified in screens for temperature-sensitive embryonic lethal mutations, emb-5 is required for the correct timing of the second E (endoderm)-cell division in the early embryo and thus, for normal embryonic gastrulation; in addition, emb-5 activity is required postembryonically for proper gonad development; in yeast two-hybrid studies, EMB-5 interacts with the intracellular domains of LIN-12 and GLP-1, suggesting that EMB-5 functions as a positive downstream effector in Notch-like signaling pathways during C. elegans development; emb-5 mRNA is most abundant during embryonic stages, with lower levels apparent during the L1-L3 larval stages, and even lower levels observed during L4. | ||
KOG Annotation  | Transcription elongation factor SPT6 |
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Evidence for Inhibition | |||
External "T04A8.14" Links | 1 | ||
Phenotype | WT |
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External Movies (Please note that RNAiDB is not hosting these data.) |
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Laboratory | TH | ||
RNAi Reagent & Type | Cenix:300-a9 (PCR_reagent) | ||
Remark | early embryonic: No significant defects. | ||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||
Delivery Method | Injection | ||
Date | 2005-3-24 | ||
Gene Plot of T04A8.14 | |||