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RNAi Experiment: Cenix:300-c6 Ace View of Cenix:300-c6
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C36E8.5 (tbb-2)
Description of "C36E8.5"  tbb-2 encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-2 is redundant for embryonic viability, due to its paralog TBB-1; however, unlike its paralog TBB-1 it is preferred for normal microtubule severing by the katanin complex MEI-1/MEI-2; TBB-2 is required together with TBB-1, TBA-1, and tba-2 to make spindle structures in embryos and TBB-2 also affects the stability of the PO spindle; first divisions are normal in null mutants, but putative gain-of-function mutations affect centrosome rotations in the P0, P1, and EMS blastomeres of the early embryo, and affect pronuclear migration and meiosis.
KOG Annotation  Beta tubulin
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:4015889..4017840)
Transcript overlap: 1515 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 1389
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 0.951
Wormbase (BLAST) RNAi primary
External "C36E8.5" Links  Wormbase NCBI Phenobank 1
Gene Inhibited  C54C6.2 (ben-1)
Description of "C54C6.2"  A beta-tubulin that confers benzimidazole sensitivity.
KOG Annotation  Beta tubulin
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 72
Relative score: 0.052 (Best raw score= for Gene )
Specificity index: 0.049
Wormbase (BLAST) RNAi secondary
External "C54C6.2" Links  Wormbase NCBI Phenobank 1
Cenix:300-c6 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Phenotype  Pnm
External Movies 
(Please note that RNAiDB is not
hosting these data.)
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Help
Cenix:300-c6 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:300-c6 (PCR_reagent)
Remark  early embryonic: Pronuclear Migration
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of C54C6.2 Browse using GBrowse
Gene Graph
Gene Plot of C36E8.5 Browse using GBrowse
Gene Graph