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RNAi Experiment: Cenix:302-f10 Ace View of Cenix:302-f10
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C14B9.4 (plk-1)
Description of "C14B9.4"  plk-1 encodes a serine/threonine polo-like kinase homologous to Drosophila polo and Saccharomyces cerevisiae CDC5; PLK-1 is required for meiotic nuclear envelope breakdown, polar body formation and extrusion, and proper chromosome segregation during meiosis, and additionally, may play a role in germline development; PLK-1 is proposed to phosphorylate REC-8, a meiotic-specific cohesin, thus promoting REC-8 degradation and subsequent separation of sister chromatids; PLK-1 is localized diffusely in the cytoplasm of mature oocytes, but during meiosis I becomes associated with pre-metaphase chromatin and then at anaphase with chromatin and the area between dividing chromatin; in embryos, PLK-1 localizes to centrosomes, metaphase chromatin, and during telophase, to the area between dividing chromatin.
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:8102444..8104617)
Transcript overlap: 1411 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 1327
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C14B9.4" Links  Wormbase NCBI Phenobank 1 2
Cenix:302-f10 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Phenotype  Complex Phenotype
External Movies 
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hosting these data.)
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Cenix:302-f10 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:302-f10 (PCR_reagent)
Remark  early embryonic: Complex Phenotype
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of C14B9.4 Browse using GBrowse
Gene Graph