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RNAi Experiment: Cenix:312-d5 Ace View of Cenix:312-d5
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C05D2.5 (gak-1)
Description of "C05D2.5"  gak-1 encodes a protein that contains an AT hook motif, a DNA-binding domain that shows a preference for binding stretches of A/T base pairs; GAK-1 appears to play a role in meiotic chromosome segregation, as overexpression results in post-prophase I chromosome segregation abnormalities, and a corresponding increase in embryonic lethality and the proportion of genotypically XO males in an otherwise self-fertile, XX hermaphrodite population; loss of gak-1 function via RNA-mediated interference (RNAi) results in sterility in the injected hermaphrodites, suggesting a possible role in germline development as well; gak-1 expression is enhanced in the germline, although its precise subcellular localization has not been reported.
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:5604792..5606977)
Transcript overlap: 1459 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 1333
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C05D2.5" Links  Wormbase NCBI Phenobank 1
Cenix:312-d5 Phenotypes Help with Phenotypes
Phenotype  WT
Cenix:312-d5 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:312-d5 (PCR_reagent)
Remark  wild type
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of C05D2.5 Browse using GBrowse
Gene Graph