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RNAi Experiment: Cenix:320-d1 Ace View of Cenix:320-d1
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  B0464.5 (spk-1)
Description of "B0464.5"  spk-1 encodes a serine/threonine kinase orthologous to the highly conserved serine/arginine-rich protein kinases (SRPKs) that phosphorylate SR proteins, essential components of the pre-mRNA splicing machinery; SPK-1, required for embryogenesis and germline development, can directly bind and phosphorylate RSP-3 (CeSF2/ASF), an SR splicing factor homolog; SPK-1 is expressed predominantly in the adult germline; SPK-1 is homologous to human RSK2, which when mutated leads to Coffin-Lowry syndrome (OMIM:303600).
KOG Annotation  Serine/threonine protein kinase
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:9460488..9462142)
Transcript overlap: 1148 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 1043
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "B0464.5" Links  Wormbase NCBI Phenobank 1 2 3
Cenix:320-d1 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Phenotype  Cyk
External Movies 
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Cenix:320-d1 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:320-d1 (PCR_reagent)
Remark  early embryonic: Cytokinesis
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of B0464.5 Browse using GBrowse
Gene Graph