RNAi Experiment: Cenix:324-a11 |
Ace View of Cenix:324-a11
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Genes Inhibited |
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Gene Inhibited |
M142.1 (unc-119) |
Description of "M142.1" |
unc-119 encodes a novel protein that is highly conserved amongst metazoans; unc-119 activity is required for proper development of the nervous system, including axonal branching and fasciculation, and hence, for normal movement, chemosensation, and feeding; unc-119 is expressed pan-neuronally beginning in the early embryo (~60 cells) and continuing through adulthood; although the molecular function of UNC-119 is not yet known, human UNC119, which can rescue C. elegans unc-119 mutant animals, is reported to function as a receptor-associated activator of signal transduction; thus, UNC-119 may be part of a signal transduction pathway that mediates axonal patterning in response to external developmental cues. |
KOG Annotation  |
Photoreceptor synaptic vesicle protein HRG4/UNC-119
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Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (III:10907428..10908754)
Transcript overlap: 706 nt |
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Sliding Window |
Raw score: 643
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "M142.1" Links |
1 |
Cenix:324-a11 Phenotypes |
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Phenotype |
WT
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Cenix:324-a11 Experiment Details |
Ace View |
Laboratory |
TH |
RNAi Reagent & Type |
Cenix:324-a11 (PCR_reagent) |
Remark |
wild type |
Reference |
Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
Delivery Method |
Injection |
Date |
2005-3-24 |
Gene Plot of M142.1 |
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