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RNAi Experiment: Cenix:326-a8 Ace View of Cenix:326-a8
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F56A8.7 (unc-64)
Description of "F56A8.7"  unc-64 encodes syntaxin, an plasma membrane receptor for intracellular vesicles that is orthologous to vertebrate syntaxin 1A (OMIM:186590) and Drosophila Syx1A; UNC-64 is required for normal locomotion and possibly also for insulin secretion; as an essential component of the core synaptic vesicle fusion machinery, UNC-64 interacts with UNC-13, a diacylglycerol-binding protein, and SNB-1/synaptobrevin; UNC-64 protein levels are reduced in an unc-18 mutant background; unc-64 mutations can be suppressed by mutations in slo-1, a calcium-activated potassium channel; UNC-64 is expressed ubiquitously in the nervous system and in secretory cells such as the uv1 cell in the vulva and excretory gland cells.
KOG Annotation  SNARE protein Syntaxin 1 and related proteins
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:13277892..13280116)
Transcript overlap: 621 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 516
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F56A8.7" Links  Wormbase NCBI Phenobank 1 2
Cenix:326-a8 Phenotypes Help with Phenotypes
Phenotype  WT
Cenix:326-a8 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:326-a8 (PCR_reagent)
Remark  wild type
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of F56A8.7 Browse using GBrowse
Gene Graph