RNAi Experiment: Cenix:327-d7 |
Ace View of Cenix:327-d7
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Genes Inhibited |
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Gene Inhibited |
C05D2.8 |
Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (III:5607441..5608748)
Transcript overlap: 675 nt |
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Sliding Window |
Raw score: 571
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "C05D2.8" Links |
1 |
Gene Inhibited |
C05D2.5 (gak-1) |
Description of "C05D2.5" |
gak-1 encodes a protein that contains an AT hook motif, a DNA-binding domain that shows a preference for binding stretches of A/T base pairs; GAK-1 appears to play a role in meiotic chromosome segregation, as overexpression results in post-prophase I chromosome segregation abnormalities, and a corresponding increase in embryonic lethality and the proportion of genotypically XO males in an otherwise self-fertile, XX hermaphrodite population; loss of gak-1 function via RNA-mediated interference (RNAi) results in sterility in the injected hermaphrodites, suggesting a possible role in germline development as well; gak-1 expression is enhanced in the germline, although its precise subcellular localization has not been reported. |
Evidence for Inhibition |
ePCR |
Transcript overlap: 59 nt |
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External "C05D2.5" Links |
1 |
Cenix:327-d7 Phenotypes |
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Phenotype |
WT
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Cenix:327-d7 Experiment Details |
Ace View |
Laboratory |
TH |
RNAi Reagent & Type |
Cenix:327-d7 (PCR_reagent) |
Remark |
early embryonic: No significant defects. 1/5 embryos has internal cell partitioning. |
Reference |
Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
Delivery Method |
Injection |
Date |
2005-3-24 |
Gene Plot of C05D2.8 |
Browse using GBrowse
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Gene Plot of C05D2.5 |
Browse using GBrowse
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