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RNAi Experiment: Cenix:33-d11 Ace View of Cenix:33-d11
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C09G4.3 (dom-6)
Description of "C09G4.3"  A homolog of Cks/Suc1, a highly conserved member of the eukaryotic cell cycle machinery that affects both meiosis and mitosis and has a role in the inactivation of the M-phase promoting factor (MPF) during early embryogenesis.
KOG Annotation  Cyclin-dependent protein kinase CDC28, regulatory subunit CKS1, and related proteins
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (IV:8513854..8515539)
Transcript overlap: 618 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 597
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C09G4.3" Links  Wormbase NCBI Phenobank 1
Gene Inhibited  C09G4.4
Evidence for Inhibition 
ePCR Transcript overlap: 50 nt Explain types of evidence for RNAi inhibition
External "C09G4.4" Links  Wormbase NCBI Phenobank 1
Gene Inhibited  C09G4.5 (mes-6)
Description of "C09G4.5"  mes-6 encodes a WD repeat-containing protein that is orthologous to Drosophila Extra sex combs (Esc); as a member of a Polycomb-like chromatin repressive complex with MES-2 and MES-3, MES-6 is required maternally for normal germline development and during larval development, for anteroposterior patterning; during germline development, the MES-2/MES-3/MES-6 complex is believed to be essential for maintaining repression of the X chromosome, and in transgenic animals, the complex is necessary for germline repression of repetitive transgenes; in axial patterning, the MES-2/MES-3/MES-6 complex is required in somatic tissues for maintaining homeotic gene repression, acting upstream of the Hox genes lin-39, mab-5, and egl-5, as well as the egl-5 target gene lin-32; MES-6 expression is detected in the nuclei of all cells during early embryogenesis, in the germline precursors Z2 and Z3 and faintly in some somatic cells during late embryogenesis and the L1 larval stage, widely in later larvae, and in germline and oocyte nuclei in adults; normal MES-6 distribution is dependent upon wild-type activity of MES-2 and MES-3, and likewise, distribution of MES-3 is dependent upon wild-type activity of MES-2 and MES-6
KOG Annotation  Transcriptional repressor EED/ESC/FIE, required for transcriptional silencing, WD repeat superfamily
What's a KOG?
Evidence for Inhibition 
ePCR Transcript overlap: 36 nt Explain types of evidence for RNAi inhibition
External "C09G4.5" Links  Wormbase NCBI Phenobank 1
Cenix:33-d11 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Phenotype  Entry Into Interphase abnormal
External Movies 
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hosting these data.)
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Cenix:33-d11 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:33-d11 (PCR_reagent)
Remark  early embryonic: Entry Into Interphase
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of C09G4.4 Browse using GBrowse
Gene Graph
Gene Plot of C09G4.3 Browse using GBrowse
Gene Graph
Gene Plot of C09G4.5 Browse using GBrowse
Gene Graph