RNAi Card Page

RNAi Experiment: Cenix:335-a4

Genes Inhibited

Gene Inhibited

Description of "K08E3.6"

cyk-4 encodes a GTPase activating protein (GAP) for the Rho family of GTPases that, together with ZEN-4, is sufficient to promote the formation of the large bundles of microtubules that form the central spindle during anaphase, and is required for fertility and coordinated locomotion postembryonically; localizes to the central spindle during anaphase interdependently with ZEN-4, and interacts with ZEN-4 in vitro and in vivo.

KOG Annotation

GTPase-activating protein

Evidence for Inhibition

ePCR	Status: Best_ePCR (III:13770397..13771254) Transcript overlap: 249 nt
Sliding Window	Raw score: 186 Relative score: 0.912 (Best raw score= for Gene ) Specificity index: 0.477
Wormbase (BLAST)	RNAi primary

External "K08E3.6" Links

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Gene Inhibited

K08E3.7 (pdr-1)

Description of "K08E3.7"

pdr-1 encodes an ortholog of human parkin (PARK2; OMIM:602544), which when mutated leads to the juvenile 2 form of Parkinson disease (OMIM:600116).

KOG Annotation

E3 ubiquitin-protein ligase (Parkin protein)

Evidence for Inhibition

ePCR	Status: Top85_percentile_ePCR (III:13770397..13771254) Transcript overlap: 246 nt
Sliding Window	Raw score: 204 Relative score: 1 (This gene has the best score for this RNAi reagent) Specificity index: 0.523
Wormbase (BLAST)	RNAi primary