RNAi Experiment: Cenix:335-c2 |
Ace View of Cenix:335-c2
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Genes Inhibited |
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Gene Inhibited |
C38C10.4 (gpr-2) |
Description of "C38C10.4" |
gpr-2 encodes a protein containing a GPR (G Protein Regulator)/GoLoco motif characteristic of guanine nucleotide exchange factors specific for G-alpha GTPases; GPR-2 appears to function redundantly during early embryogenesis and germ-line development to regulate chromosome and spindle movements during cell division; GPR-2 likely acts as a positive regulator of G protein signaling and specifically, may regulate GOA-1 signaling in the embryo; GPR-2 forms a protein complex with the nearly identical GPR-1 and with LIN-5, a coiled-coil protein that is required for proper localization of GPR-2 to the cell cortex and spindle asters of the early embryo; in addition, proper GPR-2/GPR-1/LIN-5 localization between the P2 and EMS blastomeres at the four-cell stage, which may contribute to spindle positioning in EMS, requires the MES-1/SRC-1 tyrosine kinase signaling pathway; GPR-2 is believed to act downstream of, or in parallel to, PAR-3, a PDZ domain-containing protein, in mitotic spindle positioning in the early embryo. |
Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (III:9389993..9391675)
Transcript overlap: 334 nt |
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Sliding Window |
Raw score: 292
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 0.578 |
Wormbase (BLAST) |
RNAi primary |
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External "C38C10.4" Links |
1 |
Gene Inhibited |
C38C10.2 |
Description of "C38C10.2" |
C38C10.2 is orthologous to the human gene SOLUTE CARRIER FAMILY 17 (ANION/SUGAR TRANSPORTER), MEMBER 5 (SLC17A5; OMIM:604322), which when mutated leads to disease. |
KOG Annotation  |
Permease of the major facilitator superfamily
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Evidence for Inhibition |
ePCR |
Transcript overlap: 13 nt |
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External "C38C10.2" Links |
1 |
Gene Inhibited |
F22B7.13 (gpr-1) |
Description of "F22B7.13" |
Associated GO Term : GTPase activator activity |
Evidence for Inhibition |
Sliding Window |
Raw score: 213
Relative score: 0.729 (Best raw score= for Gene )
Specificity index: 0.422 |
Wormbase (BLAST) |
RNAi primary |
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External "F22B7.13" Links |
1 |
Cenix:335-c2 Phenotypes |
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Embryonic |
Emb Penetrance None reported |
Phenotype |
Asymmetry of Division abnormal
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External Movies (Please note that RNAiDB is not hosting these data.) |
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Cenix:335-c2 Experiment Details |
Ace View |
Laboratory |
TH |
RNAi Reagent & Type |
Cenix:335-c2 (PCR_reagent) |
Remark |
early embryonic: Asymmetry of Division |
Reference |
Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
Delivery Method |
Injection |
Date |
2005-3-24 |
Gene Plot of C38C10.4 |
Browse using GBrowse
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Gene Plot of C38C10.2 |
Browse using GBrowse
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Gene Plot of F22B7.13 |
Browse using GBrowse
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