Ace View of Cenix:338-a3 | |||
Gene Inhibited | H04J21.3 (gip-1) | ||
Description of "H04J21.3" | gip-1 encodes the C. elegans homolog of Saccharomyces cerevisiae Spc98p, a gamma-tubulin-binding protein that with Spc97p forms part of a gamma-tubulin ring complex that can nucleate microtubule formation in vitro and in vivo; in C. elegans, GIP-1 is essential for embryogenesis and required for formation of centrosomal asters during interphase and formation of the mitotic spindle, but not for formation of mitotic asters; GIP-1 colocalizes with TBG-1/gamma-tubulin to centrosomes during interphase and mitosis; GIP-1 and TBG-1 are required reciprocally for centrosomal localization. | ||
Evidence for Inhibition | |||
External "H04J21.3" Links | 1 2 | ||
Embryonic | Emb Penetrance None reported | ||
Phenotype | Spindle Assembly abnormal |
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External Movies (Please note that RNAiDB is not hosting these data.) |
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Laboratory | TH | ||
RNAi Reagent & Type | Cenix:338-a3 (PCR_reagent) | ||
Remark | early embryonic: Spindle Assembly | ||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||
Delivery Method | Injection | ||
Date | 2005-3-24 | ||
Gene Plot of H04J21.3 | |||