| RNAi Experiment: Cenix:340-h4 |
Ace View of Cenix:340-h4
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| Genes Inhibited |
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| Gene Inhibited |
T20B12.2 (tbp-1) |
| Description of "T20B12.2" |
tbp-1 encodes the C. elegans ortholog of the human TATA-box-binding protein (TBP; OMIM:600075; mutated in spinocerebellar ataxia 17); consistent with its proposed role in transcriptional regulation, TBP-1 has been shown to provide TFIID-like basal transcription activity in human and C. elegans extracts, to bind specifically to a TATA box sequence, and to interact with TFIIA and TFIIB transcription factors from other species; large-scale RNA-mediated interference (RNAi) screens indicate that tbp-1 activity is required for embryonic and larval development, as well as for normal rates of postembryonic growth. |
| KOG Annotation |
TATA-box binding protein (TBP), component of TFIID and TFIIIB
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| Evidence for Inhibition |
| ePCR |
Status: Unique_ePCR (III:7384810..7385566)
Transcript overlap: 705 nt |
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| Sliding Window |
Raw score: 663
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
| Wormbase (BLAST) |
RNAi primary |
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| External "T20B12.2" Links |
   1 |
| Cenix:340-h4 Phenotypes |
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| Embryonic |
Emb Penetrance None reported |
External Movies
(Please note that RNAiDB is not
hosting these data.) |
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| Cenix:340-h4 Experiment Details |
Ace View |
| Laboratory |
TH |
| RNAi Reagent & Type |
Cenix:340-h4 (PCR_reagent) |
| Reference |
Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
| Delivery Method |
Injection |
| Date |
2005-3-24 |
| Gene Plot of T20B12.2 |
Browse using GBrowse
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