Ace View of Cenix:340-h4 | |||
Gene Inhibited | T20B12.2 (tbp-1) | ||
Description of "T20B12.2" | tbp-1 encodes the C. elegans ortholog of the human TATA-box-binding protein (TBP; OMIM:600075; mutated in spinocerebellar ataxia 17); consistent with its proposed role in transcriptional regulation, TBP-1 has been shown to provide TFIID-like basal transcription activity in human and C. elegans extracts, to bind specifically to a TATA box sequence, and to interact with TFIIA and TFIIB transcription factors from other species; large-scale RNA-mediated interference (RNAi) screens indicate that tbp-1 activity is required for embryonic and larval development, as well as for normal rates of postembryonic growth. | ||
KOG Annotation  | TATA-box binding protein (TBP), component of TFIID and TFIIIB |
||
Evidence for Inhibition | |||
External "T20B12.2" Links | ![]() ![]() ![]() |
||
Embryonic | Emb Penetrance None reported | ||
External Movies (Please note that RNAiDB is not hosting these data.) |
![]() |
||
Laboratory | TH | ||
RNAi Reagent & Type | Cenix:340-h4 (PCR_reagent) | ||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||
Delivery Method | Injection | ||
Date | 2005-3-24 | ||
Gene Plot of T20B12.2 | |||
![]() |