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RNAi Experiment: Cenix:341-a3 Ace View of Cenix:341-a3
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  R10E11.1 (cbp-1)
Description of "R10E11.1"  cbp-1 encodes a homolog of the mammalian transcriptional cofactors CBP (OMIM:600140) and p300 (E1A-BINDING PROTEIN, 300-KD; OMIM:602700) that have been shown to possess histone acetyltransferase activity, and which, when mutated, lead to Rubinstein-Taybi syndrome (OMIM:180849) and colorectal cancer (OMIM:114500); at least one splicing form of CBP-1 exhibits histone acetyltransferase (HAT) activity in vitro and has a glutamine/asparagine-rich domain; CBP-1 is required during embryogenesis for differentiation of all non-neuronal somatic cell types; CBP-1 is expressed very early in embryogenesis, suggesting that it may interact with maternally provided transcription factors, such as SKN-1, to specific developmental fates.
KOG Annotation  CREB binding protein/P300 and related TAZ Zn-finger proteins
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:9766828..9768141)
Transcript overlap: 1020 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 978
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "R10E11.1" Links  Wormbase NCBI Phenobank 1 2
Cenix:341-a3 Phenotypes Help with Phenotypes
Adult  Sterile F0/Fertility Problems
External Movies 
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Cenix:341-a3 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:341-a3 (PCR_reagent)
Remark  post-embryonic: Sterile F0/Fertility Problems
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of R10E11.1 Browse using GBrowse
Gene Graph