Ace View of Cenix:341-a3 | |||
Gene Inhibited | R10E11.1 (cbp-1) | ||
Description of "R10E11.1" | cbp-1 encodes a homolog of the mammalian transcriptional cofactors CBP (OMIM:600140) and p300 (E1A-BINDING PROTEIN, 300-KD; OMIM:602700) that have been shown to possess histone acetyltransferase activity, and which, when mutated, lead to Rubinstein-Taybi syndrome (OMIM:180849) and colorectal cancer (OMIM:114500); at least one splicing form of CBP-1 exhibits histone acetyltransferase (HAT) activity in vitro and has a glutamine/asparagine-rich domain; CBP-1 is required during embryogenesis for differentiation of all non-neuronal somatic cell types; CBP-1 is expressed very early in embryogenesis, suggesting that it may interact with maternally provided transcription factors, such as SKN-1, to specific developmental fates. | ||
KOG Annotation  | CREB binding protein/P300 and related TAZ Zn-finger proteins |
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Evidence for Inhibition | |||
External "R10E11.1" Links | 1 2 | ||
Adult | Sterile F0/Fertility Problems |
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External Movies (Please note that RNAiDB is not hosting these data.) |
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Laboratory | TH | ||
RNAi Reagent & Type | Cenix:341-a3 (PCR_reagent) | ||
Remark | post-embryonic: Sterile F0/Fertility Problems | ||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||
Delivery Method | Injection | ||
Date | 2005-3-24 | ||
Gene Plot of R10E11.1 | |||