| RNAi Experiment: Cenix:341-d11 |
Ace View of Cenix:341-d11
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| Genes Inhibited |
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| Gene Inhibited |
C36E8.5 (tbb-2) |
| Description of "C36E8.5" |
tbb-2 encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-2 is redundant for embryonic viability, due to its paralog TBB-1; however, unlike its paralog TBB-1 it is preferred for normal microtubule severing by the katanin complex MEI-1/MEI-2; TBB-2 is required together with TBB-1, TBA-1, and tba-2 to make spindle structures in embryos and TBB-2 also affects the stability of the PO spindle; first divisions are normal in null mutants, but putative gain-of-function mutations affect centrosome rotations in the P0, P1, and EMS blastomeres of the early embryo, and affect pronuclear migration and meiosis. |
| KOG Annotation |
Beta tubulin
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| Evidence for Inhibition |
| ePCR |
Status: Unique_ePCR (III:4016333..4016531)
Transcript overlap: 199 nt |
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| Sliding Window |
Raw score: 136
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
| Wormbase (BLAST) |
RNAi primary |
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| External "C36E8.5" Links |
   1 |
| Cenix:341-d11 Phenotypes |
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| Embryonic |
Emb Penetrance None reported |
| Phenotype |
Pnm
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External Movies
(Please note that RNAiDB is not
hosting these data.) |
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| Cenix:341-d11 Experiment Details |
Ace View |
| Laboratory |
TH |
| RNAi Reagent & Type |
Cenix:341-d11 (PCR_reagent) |
| Remark |
early embryonic: Pronuclear Migration |
| Reference |
Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
| Delivery Method |
Injection |
| Date |
2005-3-24 |
| Gene Plot of C36E8.5 |
Browse using GBrowse
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