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RNAi Experiment: Cenix:39-b7 Ace View of Cenix:39-b7
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  B0547.1 (csn-5)
Description of "B0547.1"  csn-5 encodes an ortholog of subunit 5 of the COP9 signalosome complex (CSN5), which in turn is a pan-eukaryotic multiprotein complex that positively regulates E3 ubiquitin ligases, physically interacts with SCF-type E3 ubiquitin ligases, and probably regulates protein degradation; CSN-5 (along with KGB-1 and ZYX-1) physically binds germline RNA helicases (GLH proteins), and csn-5(RNAi) results in sterile worms with small gonads and no oocytes, causing oogenesis to cease, but not affecting the initial assembly of P granules -- a defect essentially identical to that produced by RNAi with a combination of glh-1 and glh-4.
KOG Annotation  COP9 signalosome, subunit CSN5
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (IV:5649529..5650213)
Transcript overlap: 587 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 524
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "B0547.1" Links  Wormbase NCBI Phenobank 1
Cenix:39-b7 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Phenotype  WT_postembryonic_morphology
External Movies 
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Cenix:39-b7 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:39-b7 (PCR_reagent)
Remark  early embryonic: No significant defects observed.
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of B0547.1 Browse using GBrowse
Gene Graph