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RNAi Experiment: Cenix:55-g1 Ace View of Cenix:55-g1
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  ZK909.2 (kin-1)
Description of "ZK909.2"  kin-1 encodes multiple isoforms of a serine/threonine protein kinase that is orthologous to cAMP-dependent protein kinase (protein kinase A or PKA) catalytic subunits; KIN-1 is able to phosphorylate histone H2B in vitro and is associated with both particulate (~65%) and cytosolic (35%) cellular fractions; KIN-1 is expressed at low levels during embryogenesis, but its expression level increases in late embryogenesis, whereupon KIN-1 expression remains relatively high throughout larval and adult development; kin-1 mRNA levels, however, are fairly constant throughout development, suggesting that KIN-1 expression is regulated post-transcriptionally; as loss of kin-1 activity via large-scale RNAi screens results in no obvious defects, the precise role of kin-1 in C. elegans development and/or behavior is not yet known.
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:14949636..14950530)
Transcript overlap: 566 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 524
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "ZK909.2" Links  Wormbase NCBI Phenobank 1 2 3 4 5 6 7 8 9 10 11 12 13
Cenix:55-g1 Phenotypes Help with Phenotypes
Phenotype  WT
Cenix:55-g1 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:55-g1 (PCR_reagent)
Remark  3/3 tests are wildtype.
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of ZK909.2 Browse using GBrowse
Gene Graph