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RNAi Experiment: Cenix:63-f12 Ace View of Cenix:63-f12
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  ZK1151.1 (vab-10)
Description of "ZK1151.1"  vab-10 encodes, by alternative splicing, two spectraplakins (VAB-10A and VAB-10B) that are jointly required for mechanical resilience of the epidermis under strain by the contraction of actin microfilaments mechanically linked to fibrous organelles (FOs); VAB-10A/B are, accordingly, required for elongation during embryonic morphogenesis; VAB-10A has C-terminal plectin repeats while VAB-10B has spectrin repeats; VAB-10A is required to keep the epidermis and extracellular matrix attached via FOs, while VAB-10B is required to keep the apical and basal epidermal plasma membranes connected during morphogenesis; vab-10a and vab-10b mutations complement one another; vab-10 is orthologous to human BPAG1 (dystonin or MACF2, OMIM:113810, encoding an autoantigen of bullous pemphigoid blistering disease) and dJ562N20.1 (MACF1), and to Drosophila SHORT STOP.
KOG Annotation  Dystonin, GAS (Growth-arrest-specific protein), and related proteins
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:11774947..11775523)
Transcript overlap: 529 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 487
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "ZK1151.1" Links  Wormbase NCBI Phenobank 1
Cenix:63-f12 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Phenotype  WT_postembryonic_morphology
External Movies 
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Cenix:63-f12 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:63-f12 (PCR_reagent)
Remark  70-100% embryonic lethality. Most escapers die at larval stage.
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of ZK1151.1 Browse using GBrowse
Gene Graph