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RNAi Experiment: Cenix:72-f11 Ace View of Cenix:72-f11
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  Y48B6A.8 (ace-3)
Description of "Y48B6A.8"  ace-3 encodes one of four C. elegans acetylcholinesterases (AChE); ACE-3 represents ~5% of the total AChE activity in C. elegans and in vitro, hydrolyzes acetylthio-, butyrylthio-, and propionylthiocholine substrates with equal efficiency; although loss-of-function mutations in ace-3 result in no obvious defects, animals doubly mutant with ace-1 or ace-2 have slight defects in backward locomotion and animals triply mutant for ace-1, -2, and -3 arrest as unhatched, yet fully developed, embryos; ace-3 is the downstream gene in an operon with a fourth AChE-encoding gene, ace-4, and transcriptional reporter fusions with ace-4 upstream sequences direct expression in pharyngeal muscles pm3, 4, 5, and 7, the two CAN (canal associated neuron) cells, midbody dorsal body wall muscles in larvae, and several neurons in the head and anal ganglion
KOG Annotation  Acetylcholinesterase/Butyrylcholinesterase
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (II:14207460..14208076)
Transcript overlap: 616 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 595
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "Y48B6A.8" Links  Wormbase NCBI Phenobank 1
Cenix:72-f11 Phenotypes Help with Phenotypes
Phenotype  WT
External Movies 
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Cenix:72-f11 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:72-f11 (PCR_reagent)
Remark  early embryonic: No significant defects detected.
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of Y48B6A.8 Browse using GBrowse
Gene Graph