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RNAi Experiment: Cenix:72-g4 Ace View of Cenix:72-g4
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  K04G2.8 (apr-1)
Description of "K04G2.8"  The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39.
KOG Annotation  Beta-catenin-binding protein APC, contains ARM repeats
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:8052826..8053333)
Transcript overlap: 508 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 487
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "K04G2.8" Links  Wormbase NCBI Phenobank 1 2
Cenix:72-g4 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Phenotype  WT_postembryonic_morphology
External Movies 
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Cenix:72-g4 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:72-g4 (PCR_reagent)
Remark  early embryonic: No significant defects.
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of K04G2.8 Browse using GBrowse
Gene Graph