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RNAi Experiment: Cenix:72-h4 Ace View of Cenix:72-h4
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  K05C4.6 (hmp-2)
Description of "K05C4.6"  hmp-2 encodes a beta-catenin; HMP-2 activity is required during embryonic development for cell adhesion at adherens junctions, cell migration, and body morphogenesis; as a beta-catenin, HMP-2 likely functions solely as part of a cadherin-catenin complex, as in yeast two-hybrid assays, HMP-2 is the only C. elegans beta-catenin that binds HMP-1/alpha-catenin and HMR-1/cadherin; additionally, in the embryo, HMP-2 co-localizes to sites of epithelial cell contacts with HMP-1 and HMR-1/cadherin; however, despite its normal role in embryonic cell adhesion, HMP-2 can activate transcription and when overexpressed in vivo, can partially rescue vulval defects produced by loss of BAR-1/beta-catenin, suggesting that HMP-2 has retained the ability to interact with the Wnt signaling pathway.
KOG Annotation  Armadillo/beta-Catenin/plakoglobin
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:14741335..14741852)
Transcript overlap: 518 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 497
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "K05C4.6" Links  Wormbase NCBI Phenobank 1
Cenix:72-h4 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Phenotype  WT_postembryonic_morphology
External Movies 
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Cenix:72-h4 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:72-h4 (PCR_reagent)
Remark  early embryonic: No significant defects observed.
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of K05C4.6 Browse using GBrowse
Gene Graph