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RNAi Experiment: Cenix:75-f1 Ace View of Cenix:75-f1
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F53G12.5 (mex-3)
Description of "F53G12.5"  mex-3 encodes two KH domain-containing RNA binding proteins; in the early embryo, maternally provided MEX-3 is required for specifying the identities of the anterior AB blastomere and its descendants, as well as for the identity of the P3 blastomere and proper segregation of the germline P granules; mex-3 mRNA is distributed uniformly in the syncytial core of the adult distal gonad, mature oocytes, and early 1-cell stage embryos, but then becomes more prominent in the AB blastomere and its daughters by the 4-cell stage after which it is rapidly degraded save for the D and P4 blastomeres; MEX-3 protein is also detected uniformly in the cytoplasm of oocytes and 1-cell stage embryos, but like the mRNA, becomes more abundant in AB and its daughters at the 2- and 4-cell stages, respectively, before disappearing; MEX-3 is also detected in association with P granules from the 2-cell stage until the late stages of embryogenesis.
KOG Annotation  Predicted RNA binding protein, contains KH domain
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:128657..129295)
Transcript overlap: 511 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 448
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F53G12.5" Links  Wormbase NCBI Phenobank 1 2
Cenix:75-f1 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Phenotype  WT_postembryonic_morphology
External Movies 
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Cenix:75-f1 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:75-f1 (PCR_reagent)
Remark  early embryonic: Overall wildtype. Subtle defects within the normal range of variability.
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of F53G12.5 Browse using GBrowse
Gene Graph