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RNAi Experiment: Cenix:75-f10 Ace View of Cenix:75-f10
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  T04D1.3 (unc-57)
Description of "T04D1.3"  unc-57 encodes an ortholog of endophilin A that is required for synaptic vesicle endocytosis; UNC-57 is expressed in all neurons, at synapses and neuromuscular junctions, and (weakly) in the spermetheca; like other endophilins, UNC-57 has a large BAR domain, an N-terminal coiled-coil domain within the BAR domain, and a C-terminal SH3 domain; UNC-57 protein is necessary for proper localization of UNC-26 (synaptojanin) protein, which in turn is needed for endocytosis; unc-57 and unc-26 mutants are morphologically, ultrastructurally, and electrophysiologically similar both to one another and to double mutants, indicating that UNC-57 and UNC-26 act in a single genetic pathway.
KOG Annotation  Lysophosphatidic acid acyltransferase endophilin/SH3GL, involved in synaptic vesicle formation
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:4675176..4676040)
Transcript overlap: 544 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 481
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "T04D1.3" Links  Wormbase NCBI Phenobank 1
Cenix:75-f10 Phenotypes Help with Phenotypes
Phenotype  WT
External Movies 
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Cenix:75-f10 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:75-f10 (PCR_reagent)
Remark  early embryonic: No significant defects.
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of T04D1.3 Browse using GBrowse
Gene Graph