Ace View of Cenix:76-c5 | |||
Gene Inhibited | W02A11.4 (uba-2) | ||
Description of "W02A11.4" | uba-2 encodes the C. elegans ortholog of Saccharomyces cerevisiae Uba2p and human ubiquitin-like 2 activating enzyme E1B; by homology, UBA-2 is predicted to form, with a regulatory subunit, AOS-1, a heterodimeric enzyme that activates the ubiquitin-like protein SMO-1/SUMO in preparation for its covalent attachment to target proteins to regulate their subcellular localization and/or stability; in C. elegans, UBA-2 is required for embryogenesis and vulval development, as well as for proper Hox gene regulation; uba-2/aos-1(RNAi) animals that survive embryogenesis show ectopic expression of EGL-5 and ectopic anterior sensory ray formation. | ||
KOG Annotation  | SMT3/SUMO-activating complex, catalytic component UBA2 |
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Evidence for Inhibition | |||
External "W02A11.4" Links | 1 2 | ||
Embryonic | Emb Penetrance None reported | ||
Phenotype | WT_postembryonic_morphology |
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External Movies (Please note that RNAiDB is not hosting these data.) |
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Laboratory | TH | ||
RNAi Reagent & Type | Cenix:76-c5 (PCR_reagent) | ||
Remark | early embryonic: No significant defects seen in any of the recordings. | ||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||
Delivery Method | Injection | ||
Date | 2005-3-24 | ||
Gene Plot of W02A11.4 | |||