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RNAi Experiment: Cenix:85-f3 Ace View of Cenix:85-f3
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F39B2.2 (uev-1)
Description of "F39B2.2"  uev-1 encodes a ubiquitin-conjugating enzyme (UBC or E2) variant that contains the characteristic UBC motif, but lacks the critical active-site cysteine residue necessary for catalytic activity; as loss of UEV-1 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of UEV-1 in C. elegans development and/or behavior is not yet known; UEV-1 does, however, interact with a number of proteins, such as UBC-13, that are likely involved in the response to DNA damage; thus, UEV-1 may play a role in ubiquitination and protein turnover in conjunction with DNA repair or the DNA damage checkpoint pathway.
KOG Annotation  Ubiquitin-conjugating enzyme E2
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:14789964..14790850)
Transcript overlap: 518 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 455
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F39B2.2" Links  Wormbase NCBI Phenobank 1
Cenix:85-f3 Phenotypes Help with Phenotypes
Phenotype  WT
Cenix:85-f3 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:85-f3 (PCR_reagent)
Remark  3/3 tests are wildtype
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of F39B2.2 Browse using GBrowse
Gene Graph