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RNAi Experiment: JA:B0336.8 Ace View of JA:B0336.8
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  B0336.8 (lgg-3)
Description of "B0336.8"  lgg-3 encodes a hydrophilic protein that is orthologous to Saccharomyces cerevisiae autophagy protein Apg12p; by homology, LGG-3 is predicted to function as a modifier protein required for a protein conjugation system essential for autophagy; in the context of this conjugation system, LGG-3 is predicted to interact with Apg7p and Apg5p homologs (encoded by M7.5 and Y71G12B.12a, respectively) to effect bulk degradation of cytoplasmic components under conditions of starvation or cellular remodeling; free LGG-3 is predicted to localize to the cytoplasm, while LGG-3 conjugated to the Apg5p homolog is predicted to associate with membrane compartments; loss of lgg-3 activity via large-scale RNAi screens results in no obvious developmental or behavioral abnormalities.
KOG Annotation  Protein conjugation factor involved in autophagy
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:5697220..5698380)
Transcript overlap: 357 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 294
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "B0336.8" Links  Wormbase NCBI
Gene Inhibited  B0336.7
Description of "B0336.7"  Associated GO Term : nucleic acid binding
Evidence for Inhibition 
ePCR Transcript overlap: 46 nt Explain types of evidence for RNAi inhibition
Wormbase (BLAST) RNAi primary
External "B0336.7" Links  Wormbase NCBI
JA:B0336.8 Phenotypes Help with Phenotypes
Phenotype  WT
JA:B0336.8 Experiment Details Ace View
Laboratory  JA
RNAi Reagent & Type  sjj_B0336.8 (PCR_reagent)
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Date  2003-1-10
Gene Plot of B0336.8 Browse using GBrowse
Gene Graph
Gene Plot of B0336.7 Browse using GBrowse
Gene Graph