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RNAi Experiment: JA:C04F6.1 Ace View of JA:C04F6.1
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C04F6.1 (vit-5)
Description of "C04F6.1"  vit-5 encodes a vitellogenin, a lipid-binding protein precursor related to vertebrate vitellogenins and mammalian ApoB-100, a core LDL particle constituent; by homology, VIT-5 is predicted to function as a lipid transport protein; loss of vit-5 activity via large-scale RNA-mediated interference (RNAi) screens indicates that VIT-5 is required for embryogenesis and normal rates of postembryonic growth; VIT-5 is a major yolk component and is expressed exclusively in the adult hermaphrodite intestine from which it is secreted into the pseudocoelomic space and taken up by oocytes.
KOG Annotation  Predicted lipoprotein
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (X:3407475..3408670)
Transcript overlap: 972 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 867
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 0.436
Wormbase (BLAST) RNAi primary
External "C04F6.1" Links  Wormbase NCBI
Gene Inhibited  C04F6.4 (unc-78)
Description of "C04F6.4"  The unc-78 gene encodes a homolog of actin-interacting protein 1 (AIP1) that regulates the ordered assembly of actin and cofilin in myofibrils.
Evidence for Inhibition 
ePCR Transcript overlap: 10 nt Explain types of evidence for RNAi inhibition
External "C04F6.4" Links  Wormbase NCBI
Gene Inhibited  F59D8.1 (vit-3)
Description of "F59D8.1"  vit-3 encodes a vitellogenin, a precursor of the lipid-binding protein related to vertebrate vitellogenins and mammalian ApoB-100, a core LDL particle constituent (OMIM:107730); VIT-3 is a major yolk component, but as loss of VIT-3 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, VIT-3 likely functions redundantly with other vitellogenins to provide essential nutrients to the developing embryo; VIT-3 is expressed exclusively in the adult hermaphrodite intestine, from which it is secreted into the pseudocoelomic space and finally taken up by oocytes; in males, vit-3 expression may be negatively regulated by MAB-3, a DM binding domain-containing transcription factor required for male sexual development.
KOG Annotation  Predicted lipoprotein
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 556
Relative score: 0.641 (Best raw score= for Gene )
Specificity index: 0.28
Wormbase (BLAST) RNAi primary
External "F59D8.1" Links  Wormbase NCBI
Gene Inhibited  F59D8.2 (vit-4)
Description of "F59D8.2"  Associated GO Term : lipid transporter activity
KOG Annotation  Predicted lipoprotein
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 564
Relative score: 0.651 (Best raw score= for Gene )
Specificity index: 0.284
Wormbase (BLAST) RNAi primary
External "F59D8.2" Links  Wormbase NCBI
JA:C04F6.1 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 10 %
Larval  Gro
JA:C04F6.1 Experiment Details Ace View
Laboratory  JA
RNAi Reagent & Type  sjj_C04F6.1 (PCR_reagent)
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Date  2003-1-10
Gene Plot of C04F6.4 Browse using GBrowse
Gene Graph
Gene Plot of F59D8.1 Browse using GBrowse
Gene Graph
Gene Plot of C04F6.1 Browse using GBrowse
Gene Graph
Gene Plot of F59D8.2 Browse using GBrowse
Gene Graph