RNAi Experiment: JA:C04F6.1 |
Ace View of JA:C04F6.1
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Genes Inhibited |
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Gene Inhibited |
C04F6.1 (vit-5) |
Description of "C04F6.1" |
vit-5 encodes a vitellogenin, a lipid-binding protein precursor related to vertebrate vitellogenins and mammalian ApoB-100, a core LDL particle constituent; by homology, VIT-5 is predicted to function as a lipid transport protein; loss of vit-5 activity via large-scale RNA-mediated interference (RNAi) screens indicates that VIT-5 is required for embryogenesis and normal rates of postembryonic growth; VIT-5 is a major yolk component and is expressed exclusively in the adult hermaphrodite intestine from which it is secreted into the pseudocoelomic space and taken up by oocytes. |
KOG Annotation  |
Predicted lipoprotein
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Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (X:3407475..3408670)
Transcript overlap: 972 nt |
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Sliding Window |
Raw score: 867
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 0.436 |
Wormbase (BLAST) |
RNAi primary |
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External "C04F6.1" Links |
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Gene Inhibited |
C04F6.4 (unc-78) |
Description of "C04F6.4" |
The unc-78 gene encodes a homolog of actin-interacting protein 1 (AIP1) that regulates the ordered assembly of actin and cofilin in myofibrils. |
Evidence for Inhibition |
ePCR |
Transcript overlap: 10 nt |
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External "C04F6.4" Links |
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Gene Inhibited |
F59D8.1 (vit-3) |
Description of "F59D8.1" |
vit-3 encodes a vitellogenin, a precursor of the lipid-binding protein related to vertebrate vitellogenins and mammalian ApoB-100, a core LDL particle constituent (OMIM:107730); VIT-3 is a major yolk component, but as loss of VIT-3 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, VIT-3 likely functions redundantly with other vitellogenins to provide essential nutrients to the developing embryo; VIT-3 is expressed exclusively in the adult hermaphrodite intestine, from which it is secreted into the pseudocoelomic space and finally taken up by oocytes; in males, vit-3 expression may be negatively regulated by MAB-3, a DM binding domain-containing transcription factor required for male sexual development. |
KOG Annotation  |
Predicted lipoprotein
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Evidence for Inhibition |
Sliding Window |
Raw score: 556
Relative score: 0.641 (Best raw score= for Gene )
Specificity index: 0.28 |
Wormbase (BLAST) |
RNAi primary |
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External "F59D8.1" Links |
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Gene Inhibited |
F59D8.2 (vit-4) |
Description of "F59D8.2" |
Associated GO Term : lipid transporter activity |
KOG Annotation  |
Predicted lipoprotein
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Evidence for Inhibition |
Sliding Window |
Raw score: 564
Relative score: 0.651 (Best raw score= for Gene )
Specificity index: 0.284 |
Wormbase (BLAST) |
RNAi primary |
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External "F59D8.2" Links |
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JA:C04F6.1 Phenotypes |
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Embryonic |
Emb Penetrance 10 % |
Larval |
Gro
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JA:C04F6.1 Experiment Details |
Ace View |
Laboratory |
JA |
RNAi Reagent & Type |
sjj_C04F6.1 (PCR_reagent) |
Reference |
Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." |
Date |
2003-1-10 |
Gene Plot of C04F6.4 |
Browse using GBrowse
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Gene Plot of F59D8.1 |
Browse using GBrowse
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Gene Plot of C04F6.1 |
Browse using GBrowse
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Gene Plot of F59D8.2 |
Browse using GBrowse
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