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RNAi Experiment: JA:C05D11.5 Ace View of JA:C05D11.5
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C05D11.5
KOG Annotation  Hydroxypyruvate isomerase
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:6409878..6411539)
Transcript overlap: 817 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 712
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C05D11.5" Links  Wormbase NCBI
Gene Inhibited  C05D11.4 (let-756)
Description of "C05D11.4"  let-756 encodes an fibroblast growth factor (FGF)-like ligand that is required for progression through early larval development; LET-756 is expressed from late embryogenesis to adulthood, with a peak of expression in larvae; with EGL-17, LET-756 is redundantly required to activate EGL-15/FGFR, which in turn activates protein degradation in adult muscle cells; homozygotes for partial loss-of-function alleles are small, clear, and scrawny, but viable, while those for a null allele arrest in early larval development.
KOG Annotation  Fibroblast growth factor
What's a KOG?
Evidence for Inhibition 
ePCR Transcript overlap: 78 nt Explain types of evidence for RNAi inhibition
External "C05D11.4" Links  Wormbase NCBI
Gene Inhibited  C05D11.6 (nas-4)
Description of "C05D11.6"  nas-4 encodes a predicted extracellular matrix metalloprotease of the M12A (astacin) family that contains an N-terminal signal sequence and a catalytic domain, but no recognizable regulatory domains in the C-terminus; as loss of nas-4 activity via RNAi results in no obvious abnormalities, the precise role of NAS-4 in C. elegans development and/or behavior is not yet known; however, an NAS-4 translational reporter is expressed in the pharynx and intestine in larvae and adults, suggesting a role for NAS-4 in digestion; NAS-4 is specifically detected within cells of the pharyngeal procorpus, metacorpus, isthmus, and terminal bulb, with extracellular expression detected in the lumen of the terminal bulb and in the gut.
KOG Annotation  Meprin A metalloprotease
What's a KOG?
Evidence for Inhibition 
ePCR Transcript overlap: 4 nt Explain types of evidence for RNAi inhibition
External "C05D11.6" Links  Wormbase NCBI
JA:C05D11.5 Phenotypes Help with Phenotypes
Phenotype  WT
JA:C05D11.5 Experiment Details Ace View
Laboratory  JA
RNAi Reagent & Type  sjj_C05D11.5 (PCR_reagent)
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Date  2003-1-10
Gene Plot of C05D11.4 Browse using GBrowse
Gene Graph
Gene Plot of C05D11.6 Browse using GBrowse
Gene Graph
Gene Plot of C05D11.5 Browse using GBrowse
Gene Graph