RNAi Experiment: JA:C10H11.9 |
Ace View of JA:C10H11.9
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Genes Inhibited |
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Gene Inhibited |
C10H11.9 (let-502) |
Description of "C10H11.9" |
let-502 encodes Rho-binding Ser/Thr kinase orthologous to human myotonic dystrophy kinase (DM-kinase), and is required for early embryonic cleavages, embryonic elongation, migration of hypodermal P cells to a ventral position, normal spermathecal contraction, and fertility; LET-502 is required for hypodermal cells to properly change their shape, and is expressed in those cells, during embryonic elongation; let-502 mutations are suppressed by mel-11 mutations, and the pattern of LET-502 expression in the embryonic epidermis and the spermatheca is opposite to that of MEL-11, indicating that LET-502 and MEL-11 have opposing functions (presumably tissue contraction and relaxation); MEL-11 requires LET-502 (along with the nonmuscle myosin NMY-1) for proper localization. |
KOG Annotation  |
Rho-associated, coiled-coil containing protein kinase
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Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (I:4742449..4743523)
Transcript overlap: 800 nt |
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Sliding Window |
Raw score: 738
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "C10H11.9" Links |
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JA:C10H11.9 Phenotypes |
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Embryonic |
Emb Penetrance 50 - 80 % Led (1-2fold) |
Larval |
Lvl
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Adult |
Dpy
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Phenotype |
Rol
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Movies/Stacks/Images |
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JA:C10H11.9 Experiment Details |
Ace View |
Laboratory |
JA |
RNAi Reagent & Type |
sjj_C10H11.9 (PCR_reagent) |
Reference |
Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...." |
Date |
2000-11-16 |
Gene Plot of C10H11.9 |
Browse using GBrowse
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