Link to C14A4.3Link to C14A4.4aLink to C14A4.4bLink to C14A4.5RNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentgeneMap
Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
 
RNAi Experiment: JA:C14A4.4 Ace View of JA:C14A4.4
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C14A4.4 (crn-3)
Description of "C14A4.4"  crn-3 encodes a cell death-related nuclease, homologous to the 100 kDa polymyositis/scleroderma autoantigen (PM/Scl-100), that is required for normal levels of DNA degradation during apoptosis; PM/Scl-100 is a ribonuclease component of the multiexonuclease exosome complex, which processes or degrades several types of RNAs in yeast; crn-3(RNAi) animals show retarded growth and a low penetrance of embryonic lethality; CRN-3 promotes both DNA degradation and cell corpse engulfment, in a partially redundant pathway that includes CRN-2 but is parallel to CPS-6; CRN-3 is predicted to be mitochondrial.
Evidence for Inhibition 
ePCR Status: Unique_ePCR (II:10588741..10589775)
Transcript overlap: 957 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 936
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C14A4.4" Links  Wormbase NCBI
JA:C14A4.4 Phenotypes Help with Phenotypes
Larval  Gro
Phenotype  Pch
JA:C14A4.4 Experiment Details Ace View
Laboratory  JA
RNAi Reagent & Type  sjj_C14A4.4 (PCR_reagent)
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Date  2003-1-10
Gene Plot of C14A4.4 Browse using GBrowse
Gene Graph