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RNAi Experiment: JA:C17D12.4 Ace View of JA:C17D12.4
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C17D12.2 (unc-75)
Description of "C17D12.2"  unc-75 encodes an RNA-binding protein with two N-terminal RNA recognition motifs (RRMs), a glutamine/asparagine-rich linker domain, and a third C-terminal RRM; UNC-75 is orthologous to mammalian CELF/BrunoL proteins that control pre-mRNA splicing; unc-75 is expressed in all neurons and in neurosecretory gland cells, and is required for normal modulation of GABA- and acetylcholine-mediated neurotransmission; UNC-75 protein is found with other RRM proteins in dynamic nuclear speckles, consistent with a role in alternative mRNA splicing; unc-75 mutations can be rescued in vivo by a human unc-75 transgene, but not by exc-7 or W02D3.11, indicating that UNC-75 acts on evolutionarily conserved but highly specific pre-mRNA substrates; both UNC-75 and EXC-7 are required in parallel for normal cholinergic neurotransmission.
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:11591685..11592792)
Transcript overlap: 105 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 84
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C17D12.2" Links  Wormbase NCBI
JA:C17D12.4 Phenotypes Help with Phenotypes
Phenotype  WT
JA:C17D12.4 Experiment Details Ace View
Laboratory  JA
RNAi Reagent & Type  sjj_C17D12.4 (PCR_reagent)
Reference  Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...."
Date  2000-11-16
Gene Plot of C17D12.2 Browse using GBrowse
Gene Graph