Link to C43E11.6d.1Link to C43E11.6d.2Link to C43E11.6e.2Link to C43E11.6d.3Link to C43E11.6aLink to C43E11.6cLink to C43E11.6bLink to C43E11.6e.1RNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentgeneMap
Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
RNAi Experiment: JA:C43E11.6 Ace View of JA:C43E11.6
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C43E11.6 (nab-1)
Description of "C43E11.6"  nab-1 encodes a PDZ and SAM domain-containing protein that is the sole C. elegans ortholog of the mammalian Neurabin/Spinophilin proteins; by homology, NAB-1 is predicted to interact with F-actin, ZYG-8/Doublecortin and the SAD-1 serine/threonine kinase to regulate interactions between the actin and microtubule networks during cell migration, growth cone guidance, and cell division; loss of nab-1 activity via RNAi has been reported to result in early embryonic lethality, dumpy and left-handed roller animals, as well as abnormalities in germ-line development and vulval morphogenesis; in large-scale screens, nab-1 RNAi did not result in any obvious abnormalities; NAB-1 translational reporter fusions show expression in hypodermal cells, neurons, and muscle.
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:4234010..4235165)
Transcript overlap: 863 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 822
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C43E11.6" Links  Wormbase NCBI
JA:C43E11.6 Phenotypes Help with Phenotypes
Phenotype  WT
JA:C43E11.6 Experiment Details Ace View
Laboratory  JA
RNAi Reagent & Type  sjj_C43E11.6 (PCR_reagent)
Reference  Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...."
Date  2000-11-16
Gene Plot of C43E11.6 Browse using GBrowse
Gene Graph