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RNAi Experiment: JA:C47D12.8 Ace View of JA:C47D12.8
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C47D12.8
Description of "C47D12.8"  C47D12.8 encodes an ortholog of the DNA repair protein XPF/ERCC4, which when mutated in humans leads to xeroderma pigmentosum (complementation group F; OMIM:133520); C47D12.8(RNAi) animals are hypersensitive to ultraviolet radiation, with increased germ cell apoptosis and embryonic lethality; C47D12.8 protein interacts with F10G8.7 (an ERCC1 ortholog) in yeast two-hybrid assays; C47D12.8 is expressed broadly in both embryonic and postembryonic animals, and is required for embryonic development; C47D12.8 is upregulated in dauers, and shares an operon with kel-1 and VF13D12L.3.
KOG Annotation  Structure-specific endonuclease ERCC1-XPF, catalytic component XPF/ERCC4
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (II:11696345..11697985)
Transcript overlap: 1072 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 988
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C47D12.8" Links  Wormbase NCBI
JA:C47D12.8 Phenotypes Help with Phenotypes
Phenotype  WT
JA:C47D12.8 Experiment Details Ace View
Laboratory  JA
RNAi Reagent & Type  sjj_C47D12.8 (PCR_reagent)
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Date  2003-1-10
Gene Plot of C47D12.8 Browse using GBrowse
Gene Graph