Link to C55B7.8RNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentgeneMap
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RNAi Experiment: JA:C55B7.8 Ace View of JA:C55B7.8
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C55B7.8 (dbr-1)
Description of "C55B7.8"  dbr-1 encodes a homolog of the RNA lariat-debranching enzyme; DBR-1 is predicted to function in RNA processing by hydrolyzing the 2'-5' phosphodiester bond at the branchpoint of excised lariat intron RNA, thus converting the introns into linear molecules that can subsequently be degraded by exonucleases; in C. elegans, DBR-1 activity is required for embryonic and germline development, as well as for normal rates of postembryonic growth; overexpression of C. elegans DBR-1 in Saccharomyces cerevisiae can complement the RNA processing defects of a dbr1 null mutant strain, restoring debranching activity and intron degradation to near wild-type levels.
KOG Annotation  RNA lariat debranching enzyme
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:6491583..6492683)
Transcript overlap: 883 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 799
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C55B7.8" Links  Wormbase NCBI
JA:C55B7.8 Phenotypes Help with Phenotypes
Phenotype  WT
JA:C55B7.8 Experiment Details Ace View
Laboratory  JA
RNAi Reagent & Type  sjj_C55B7.8 (PCR_reagent)
Reference  Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...."
Date  2000-11-16
Gene Plot of C55B7.8 Browse using GBrowse
Gene Graph