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RNAi Experiment: JA:F18A12.8 Ace View of JA:F18A12.8
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F18A12.8
Description of "F18A12.8"  F18A12.8 encodes two isoforms of a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F18A12.8A is closely paralogous to ZK20.6, and orthologous to CG9761 in Drosophila melanogaster; F18A12.8 is homologous, and possibly orthologous, to human ECE1 (OMIM:600423; mutation leads to Hirschsprung disease, cardiac defects, and autonomic dysfunction); more generally, F18A12.8A falls into a group of proteins that includes the classical neprilysins found in mammals (e.g., PEX [OMIM:307800] and the enkephalin cleaving enzymes).
Evidence for Inhibition 
ePCR Status: Unique_ePCR (II:3421852..3422970)
Transcript overlap: 829 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 766
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F18A12.8" Links  Wormbase NCBI
JA:F18A12.8 Phenotypes Help with Phenotypes
Phenotype  WT
JA:F18A12.8 Experiment Details Ace View
Laboratory  JA
RNAi Reagent & Type  sjj_F18A12.8 (PCR_reagent)
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Date  2003-1-10
Gene Plot of F18A12.8 Browse using GBrowse
Gene Graph