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RNAi Experiment: JA:F25F8.2 Ace View of JA:F25F8.2
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F25F8.2 (glc-2)
Description of "F25F8.2"  glc-2 encodes the beta subunit of a glutamate-gated chloride channel; in vivo, GLC-2 is capable of forming homomeric glutamate-activated channels, as well as heteromeric channels with GLC-1 that can be activated by glutamate and avermectins, antihelmintics that inhibit pharyngeal pumping; as loss of glc-2 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GLC-2 in development and/or behavior is not yet known; however, GLC-2 expression is generally restricted to the pm4 pharyngeal muscles of larvae and adults, suggesting a role for GLC-2 in regulation of glutamatergic inhibition of pharyngeal pumping.
KOG Annotation  Ligand-gated ion channel
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:4885176..4886849)
Transcript overlap: 858 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 753
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F25F8.2" Links  Wormbase NCBI
JA:F25F8.2 Phenotypes Help with Phenotypes
Phenotype  WT
JA:F25F8.2 Experiment Details Ace View
Laboratory  JA
RNAi Reagent & Type  sjj_F25F8.2 (PCR_reagent)
Reference  Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...."
Date  2000-11-16
Gene Plot of F25F8.2 Browse using GBrowse
Gene Graph