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RNAi Experiment: JA:F26E4.10 Ace View of JA:F26E4.10
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F26E4.10 (drsh-1)
Description of "F26E4.10"  drsh-1 encodes a predicted RNase III-type ribonuclease that is orthologous to Drosophila and human Drosha; by homology, DRSH-1 is predicted to function as an endoribonuclease that, in the nucleus, initiates cleavage of primary miRNA transcripts (pri-mRNAs) into pre-miRNAs that are then exported to the cytoplasm for further processing; loss of drsh-1 activity via RNAi results in re-expression of a let-7-silenced reporter in adults, suggesting that DRSH-1 is required for let-7 processing; in addition, DRSH-1 also appears to be required for fertility, as adults lacking drsh-1 activity are sterile; along with PASH-1, a double-stranded RNA binding protein, DRSH-1 may be part of a conserved multiprotein complex that regulates nuclear pri-miRNA splicing.
KOG Annotation  Ribonuclease
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:9783555..9784714)
Transcript overlap: 994 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 931
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F26E4.10" Links  Wormbase NCBI
JA:F26E4.10 Phenotypes Help with Phenotypes
Phenotype  WT
JA:F26E4.10 Experiment Details Ace View
Laboratory  JA
RNAi Reagent & Type  sjj_F26E4.10 (PCR_reagent)
Reference  Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...."
Date  2000-11-16
Gene Plot of F26E4.10 Browse using GBrowse
Gene Graph