Link to F45H11.4RNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentgeneMap
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RNAi Experiment: JA:F45H11.4 Ace View of JA:F45H11.4
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F45H11.4 (mgl-2)
Description of "F45H11.4"  mgl-2 encodes a Group I metabotropic glutamate receptor (OMIM:604473, 604102, loss-of-function mutations in mice are associated with defects in long-term potentiation); by homology, MGL-2 is predicted to function as a post-synaptic G protein-coupled receptor that, in response to glutamate binding, stimulates phospholipase C activity and increases neuronal excitation, and in mammalian tissue culture cells, glutamate stimulation of MGL-2 does result in increased phosphoinositide turnover; a mutation in mgl-2 indicates that it is required for normal head movements and tap reversal reflexes, while loss of mgl-2 activity via large-scale RNAi screens indicates that MGL-2 is also required for embryogenesis; a mgl-2::GFP reporter is expressed in interneurons.
KOG Annotation  Glutamate-gated metabotropic ion channel receptor subunit GRM2 and related subunits, G-protein coupled receptor superfamily
bZIP transcription factor MafK
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:10386377..10387567)
Transcript overlap: 758 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 674
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F45H11.4" Links  Wormbase NCBI
JA:F45H11.4 Phenotypes Help with Phenotypes
Phenotype  WT
JA:F45H11.4 Experiment Details Ace View
Laboratory  JA
RNAi Reagent & Type  sjj_F45H11.4 (PCR_reagent)
Reference  Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...."
Date  2000-11-16
Gene Plot of F45H11.4 Browse using GBrowse
Gene Graph