Link to F53G12.5bLink to F53G12.5a.1Link to F53G12.5a.2RNAiRNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentgeneMap
Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
RNAi Experiment: JA:F53G12.5 Ace View of JA:F53G12.5
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F53G12.5 (mex-3)
Description of "F53G12.5"  mex-3 encodes two KH domain-containing RNA binding proteins; in the early embryo, maternally provided MEX-3 is required for specifying the identities of the anterior AB blastomere and its descendants, as well as for the identity of the P3 blastomere and proper segregation of the germline P granules; mex-3 mRNA is distributed uniformly in the syncytial core of the adult distal gonad, mature oocytes, and early 1-cell stage embryos, but then becomes more prominent in the AB blastomere and its daughters by the 4-cell stage after which it is rapidly degraded save for the D and P4 blastomeres; MEX-3 protein is also detected uniformly in the cytoplasm of oocytes and 1-cell stage embryos, but like the mRNA, becomes more abundant in AB and its daughters at the 2- and 4-cell stages, respectively, before disappearing; MEX-3 is also detected in association with P granules from the 2-cell stage until the late stages of embryogenesis.
KOG Annotation  Predicted RNA binding protein, contains KH domain
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:131455..133668)
Transcript overlap: 788 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 704
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F53G12.5" Links  Wormbase NCBI
JA:F53G12.5 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 100 % Led (Differentiated, not enclosed)
Movies/Stacks/Images  /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif Help
JA:F53G12.5 Experiment Details Ace View
Laboratory  JA
RNAi Reagent & Type  sjj_F53G12.5 (PCR_reagent)
Remark  cytokinesis defects seen in rare cases
Reference  Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...."
Date  2000-11-16
Gene Plot of F53G12.5 Browse using GBrowse
Gene Graph