RNAi Experiment: JA:F53G12.5 |
Ace View of JA:F53G12.5
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Genes Inhibited |
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Gene Inhibited |
F53G12.5 (mex-3) |
Description of "F53G12.5" |
mex-3 encodes two KH domain-containing RNA binding proteins; in the early embryo, maternally provided MEX-3 is required for specifying the identities of the anterior AB blastomere and its descendants, as well as for the identity of the P3 blastomere and proper segregation of the germline P granules; mex-3 mRNA is distributed uniformly in the syncytial core of the adult distal gonad, mature oocytes, and early 1-cell stage embryos, but then becomes more prominent in the AB blastomere and its daughters by the 4-cell stage after which it is rapidly degraded save for the D and P4 blastomeres; MEX-3 protein is also detected uniformly in the cytoplasm of oocytes and 1-cell stage embryos, but like the mRNA, becomes more abundant in AB and its daughters at the 2- and 4-cell stages, respectively, before disappearing; MEX-3 is also detected in association with P granules from the 2-cell stage until the late stages of embryogenesis. |
KOG Annotation  |
Predicted RNA binding protein, contains KH domain
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Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (I:131455..133668)
Transcript overlap: 788 nt |
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Sliding Window |
Raw score: 704
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "F53G12.5" Links |
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JA:F53G12.5 Phenotypes |
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Embryonic |
Emb Penetrance 100 % Led (Differentiated, not enclosed) |
Movies/Stacks/Images |
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JA:F53G12.5 Experiment Details |
Ace View |
Laboratory |
JA |
RNAi Reagent & Type |
sjj_F53G12.5 (PCR_reagent) |
Remark |
cytokinesis defects seen in rare cases |
Reference |
Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...." |
Date |
2000-11-16 |
Gene Plot of F53G12.5 |
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